HCN Domain is Necessary for Surface Expression of HCN Channels
نویسندگان
چکیده
منابع مشابه
HCN channels and heart rate.
Hyperpolarization and Cyclic Nucleotide (HCN) -gated channels represent the molecular correlates of the "funny" pacemaker current (I(f)), a current activated by hyperpolarization and considered able to influence the sinus node function in generating cardiac impulses. HCN channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channe...
متن کاملHCN channels contribute to serotonergic modulation of ventral surface chemosensitive
1 2 HCN channels contribute to serotonergic modulation of ventral surface chemosensitive 3 neurons and respiratory activity. 4 5 Virginia E. Hawkins 1* , Joanna M. Hawryluk 1* , Ana C. Takakura 2 , Anastasios V. Tzingounis 1 , 6 Thiago S. Moreira 3 , Daniel K. Mulkey 1 7 8 1 Dept. of Physiology and Neurobiology, Univ. of Connecticut, Storrs, CT 06269, USA 9 2 Dept. of Pharmacology, Univ. of Sao...
متن کاملHCN Channels Modulators: The Need for Selectivity
Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, the molecular correlate of the hyperpolarization-activated current (If/Ih), are membrane proteins which play an important role in several physiological processes and various pathological conditions. In the Sino Atrial Node (SAN) HCN4 is the target of ivabradine, a bradycardic agent that is, at the moment, the only drug which s...
متن کاملPresynaptic HCN Channels Regulate Vesicular Glutamate Transport
The amount of neurotransmitter stored in synaptic vesicles determines postsynaptic quantal size and thus the strength of synaptic transmission. However, little is known about regulation of vesicular neurotransmitter uptake. In recordings from the calyx of Held, a giant mammalian glutamatergic synapse, we found that changes in presynaptic Na(+) concentration above and below a resting value of 13...
متن کاملCooperative Gating between Single HCN Pacemaker Channels
HCN pacemaker channels (I(f), I(q), or I(h)) play a fundamental role in the physiology of many excitable cell types, including cardiac myocytes and central neurons. While cloned HCN channels have been studied extensively in macroscopic patch clamp experiments, their extremely small conductance has precluded single channel analysis to date. Nevertheless, there remain fundamental questions about ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.11.1514